Compartmental Gates and Contact Sites in Cells

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. This SFB-initiative is committed to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.



Funded by the     



November 17th 2016

Prof. Dr. Manfred J. Schmitt: Compartmental A/B toxin trafficking in yeast


November 24th 2016

Prof. Dr. Michael Knop: Systems approaches based on fluorescent protein technology to map protein degradation pathways by degrons and substrates


Copernicus Award to Peter Rehling

Peter Rehling received the Nicolaus Copernicus Polish-German Research Award 2016


Gottfried Wilhelm Leibniz Prize to Marina Rodnina

Marina Rodnina received the Gottfried Wilhelm Leibniz Prize 2016


ERC Starting Grant for Alexander Stein

The European Research Council promotes the research of Alexander Stein by an ERC Starting Grant