Compartmental Gates and Contact Sites in Cells

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. This SFB-initiative is committed to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.



Funded by the     

Symposium: Compartmental Contact Sites & Transport Processes

June 17th-19th, 2018, at the

Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, Göttingen




July 13th 2018

Tamas Balla, M.D., Ph.D.: Using PI4P gradients for lipid transport at membrane contact sites


ERC Advanced Grant for Marina Rodnina

ERC Advanced Grant for Marina Rodnina, Max Planck Institute for Biophysical Chemistry, Göttingen