Compartmental Gates and Contact Sites in Cells

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. This SFB-initiative is commited to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.

 

 

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Seminar

February 17th 2017

Luca Scorrano

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November 24th 2016

Michael Knop

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Copernicus Award to Peter Rehling

Peter Rehling received the Nicolaus Copernicus Polish-German Research Award 2016

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Gottfried Wilhelm Leibniz Prize to Marina Rodnina

Marina Rodnina received the Gottfried Wilhelm Leibniz Prize 2016

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ERC Starting Grant for Alexander Stein

The European Research Council promotes the research of Alexander Stein by an ERC Starting Grant

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