Compartmental Gates and Contact Sites in Cells

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. This SFB-initiative is committed to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.

 

 

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Seminar

June 28th 2017

Jonathan Soboloff, PhD: Multifaceted control of calcium signals by STIM1 at ER-PM junctions

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July 5th 2017

Dr. Rúben Fernández Busnadiego: Unravelling the structure of toxic protein aggregates in situ

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Maya Schuldiner receives EMBO Gold Medal 2017

Maya Schuldiner from the Weizmann Institute of Science is the recipient of the 2017 EMBO Gold Medal

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