Compartmental Gates and Contact Sites in Cells

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. This SFB-initiative is committed to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.



Funded by the     



October 19th 2017

Prof. Jeffrey Gerst: Intracellular and intercelular mRNA trafficking


October 24th 2017

Prof. Agnieszka Chacinska: Mitochondria and cellular protein homeostasis


Maya Schuldiner receives EMBO Gold Medal 2017

Maya Schuldiner from the Weizmann Institute of Science is the recipient of the 2017 EMBO Gold Medal