Compartmental Gates and Contact Sites in Cells

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. This SFB-initiative is committed to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.

 

 

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Seminar

August 31st 2018

Cristina Arrigoni, PhD: Searching for a thermosensor: unfolding transition controls temperature dependent activation in a voltage-gated channel

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ERC Advanced Grant for Marina Rodnina

ERC Advanced Grant for Marina Rodnina, Max Planck Institute for Biophysical Chemistry, Göttingen

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