Compartmental Gates and Contact Sites in Cells

The compartmentalization of cells ensures a highly specific distribution of nucleic acids, proteins and metabolites. At the same time, intracellular compartments must communicate and exchange molecules. Two major systems enable exchange between compartments: compartmental gates and contact sites. While compartmental gates mediate the selective partitioning of molecules between cytoplasm and organelles or within a membrane, contact sites represent direct physical connections between compartment-enclosing membranes. Thus, within living cells, compartmental gates and contact sites represent two complementary systems, which functionally cooperate or directly interact with each other to coordinate compartmentalized processes. This SFB-initiative is committed to addressing the role of compartmental gates and contact sites in cellular organization and physiology. We aim to understand how they achieve a selective distribution of molecules and thus functionally define and diversify cellular compartments.

 

 

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Seminar

December 12th 2019

Dr. Dorothee Dormann: Multiple roles of nuclear import receptors in protein aggregation diseases

 

 

 

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December 5th 2019

Dr. Ute Kothe: Functional link between RNA Modification and RNA Folding

 

 

 

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New paper in Nature by Ira Milosevic and Nuno Raimundo

Mitochondrial fission requires DRP1 but not dynamins.
Nature 570, E34-E42 (2019)

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ERC Advanced Grant for Stefan Jakobs

Stefan Jakobs, University Medical Center Göttingen, received an ERC Advanced Grant.

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