Investigation of the compositional, positional and functional heterogeneity of MICOS clusters in single mammalian cells
The mitochondrial contact site and cristae organizing system (MICOS) is a large multi-subunit complex in the inner membrane of mitochondria that is required for the maintenance of cristae junctions and that connects the mitochondrial inner membrane to outer membrane proteins. This project aims to investigate the compositional and functional heterogeneity of MICOS clusters with respect to their sub-mitochondrial localizations using optical nanoscopy and electron microscopy.
Prof. Dr. Stefan Jakobs
University Medical Center Göttingen
Clinic of Neurology
+49 551 201 2531 (phone)