Maintenance and functional coupling of ER contacts with the plasma membrane
The endoplasmic reticulum (ER) differentiates a peripheral membrane network of sheets, tubules, and ER contacts with the plasma membrane (PM). While ER tubules were suggested to store intracellular Ca2+, in cardiac myocytes Ca2+ release through ryanodine receptors (RyRs) is clustered in ER sheets at thousands of PM contacts and separate from Ca2+ uptake through Ca2+-ATPase pumps. We investigate the domain nature of local ER Ca2+ regulation and how it interfaces with protein synthesis in ER cisternae through translocon and alternative pathways in cardiac myocytes.
Prof. Dr. Stephan Lehnart
University Medical Center Göttingen
Clinic of Cardiology and Pneumology
+49 551 39 10575 (phone)