Project P06

Physiological role and molecular mechanism of piecemeal microautophagy of the nucleus in Saccharomyces cerevisiae

In S. cerevisiae starvation induces removal of non-essential parts of the nucleus in a process termed piecemeal microautophagy of the nucleus (PMN). During PMN vesicles filled with nuclear components bud into the vacuole at nucleus-vacuole contact sites. These organellar contact sites formed by interaction of the vacuolar protein Vac8 with the ER integral membrane protein Nvj1 are crucial for the occurrence of PMN. The longterm goals of this project are a comprehensive understanding of the mechanism of PMN, the components involved and its physiological functions.

Taken from: Krick, R., Mühe, Y., Prick, T., Bredschneider, M., Bremer, S., Wenzel, D., Eskelinen E.-L. and Thumm, M. (2009). Piecemeal microautophagy of the nucleus: genetic and morphological traits. Autophagy, 5(2), 270-272.

Principal investigator

Prof. Dr. Michael Thumm

University Medical Center Göttingen
Department of Cellular Biochemistry
Humboldtallee 23
D-37073 Göttingen

+49 551 39 5958 (phone)
mthumm(at) (e-mail)