Project P10

Diffusion trapping of neurotransmitter receptors at GABAergic synapses - cell biology and molecular mechanisms

Interneuronal synapses are the key signalling units in the brain, and the process of neurotransmitter receptor clustering at postsynaptic membranes is a key determinant of synapse efficacy. We plan (i) to decipher the cellular mechanisms by which the cell adhesion protein Neurologin-2, the guanine nucleotide exchange factor Collybistin, and the scaffold protein Gephyrin create a diffusion trap to recruit and anchor GABAA receptors at developing synapses, and (ii) to determine what proteins operate at GABAergic synapses that do not require Neuroligin-2 or Collybistin. We expect that our studies will lead to a comprehensive molecular and cell biological understanding of the genesis of GABAergic synapses and of their function in health and disease.

Principal investigator

Prof. Dr. Nils Brose

Max Planck Institute for Experimental Medicine
Hermann-Rein-Straße 3
D-37075 Göttingen

+49 551 3899 725 (phone)
brose(at) (e-mail)