Mapping cellular contact sites and their interplay
Membrane contact sites enable communication and coordination between the various cellular organelles. However we still do not know what are all the existing contact sites, what are the protein tethers holding membranes together and how the extent of contact is regulated. We will combine high-content screening tools alongside in depth biochemical characterization to map the repertoire of yeast contact sites, uncover the molecular tethers for contact where this is unknown and study the regulation of contact expansion and retraction. By answering these questions we hope to shed light on the diversity of cellular contact sites and their regulatory interplay that allows the cell to function as one coherent living unit through the changing requirements of life.
Prof. Dr. Maya Schuldiner
Weizmann Institute of Science
Department of Molecular Genetics
234 Herzl st, Rehovot
972 8 9346346 (phone)