Project Z02

Mass spectrometry based proteomics

The mass spectrometric analysis of biomolecules has been established as one of the most powerful methods for the quantitative analysis of the entire proteome including protein modifications, and hence nowadays plays a central role in cell biological research. Moreover, mass spectrometry has recently entered the field of structure biology as well. The Z02 project will provide its portfolio of mass spectrometric techniques to the members of the CRC. The main focus will be on the quantitative mass spectrometry-based interaction analyses of protein complexes at the various compartmental gates in the cell. Special attention will be devoted to the so-called APEX technology that uses biotinylation and affinity purification to enable mass spectrometric analyses of proteins at the compartmental gates, as well as of proteins within the compartments itself.

Principal investigator

Prof. Dr. Henning Urlaub

University Medical Center Göttingen

Department of Clinical Chemistry

Robert-Koch-Straße 40

D-37073 Göttingen

+49 551 39 8506 (phone)

hurlaub(at)gwdg.de (e-mail)

 

Bioanalytical Massspectrometry

Max Planck Institute for Biophysical Chemistry

Am Faßberg 11

D-37077 Göttingen

+49 551 201 1060 (phone)