Mass spectrometry based proteomics
The mass spectrometric analysis of biomolecules has been established as one of the most powerful methods for the quantitative analysis of the entire proteome including protein modifications, and hence nowadays plays a central role in cell biological research. Moreover, mass spectrometry has recently entered the field of structure biology as well. The Z02 project will provide its portfolio of mass spectrometric techniques to the members of the CRC. The main focus will be on the quantitative mass spectrometry-based interaction analyses of protein complexes at the various compartmental gates in the cell. Special attention will be devoted to the so-called APEX technology that uses biotinylation and affinity purification to enable mass spectrometric analyses of proteins at the compartmental gates, as well as of proteins within the compartments itself.
Prof. Dr. Henning Urlaub
University Medical Center Göttingen
Department of Clinical Chemistry
+49 551 39 8506 (phone)