Project P19 N

Mechanism of initiating autophagosome biogenesis on ER membrane

Upon starvation, autophagy is dramatically upregulated and initiates the recycling of nutrients. It captures cellular targets into a specialized ab initio formed double membrane autophagosome originating from a few discrete contacts with the ER. However, the molecular mechanisms that control the initiation in space and time are unclear. We will address these questions in a reconstituted system with purified recombinant human proteins, where we aim to define the minimal machinery and identify the concepts and principles that govern this process.

Principal investigator

Dr. Alex Faesen

Max Planck Institute for Biophysical Chemistry
Am Faßberg 11
D-37077 Göttingen

+49 551 201 1155 (phone)
afaesen(at) (e-mail)